陈大朋，生物化学与分子生物学博士，教授，上海中医药大学博士后，研究生导师，任职于大连医科大学比较医学教研室。辽宁省“百千万人才工程”万人计划入选者，大连市科技之星，大连市青年才俊。主持国家自然科学基金1项，大连市高层次人才创新计划1项，省级及市级、横向课题10余项。
研究聚焦：
（1）炎症性肠病、结肠炎相关结肠癌病理机制研究；
（2）中草药在炎症性肠病中抗炎以及调控黏膜屏障功能的物质基础及分子机制；
（3）源于天然的酶抑制剂高效发现以及抗炎作用研究。
课题组已经陆续筛选100余种中药材以及源于药用植物的单体化合物，解析其对炎症性肠病的调控作用和作用机制。Pharmacology & Therapeutics，Pharmacological Research，Journal of Ethnopharmacology等期刊特约审稿人，Frontiers in Pharmacology学术主编。辽宁省自然科学学术成果奖二等奖，以通讯作者/第一作者发表SCI论文40余篇，个人H-index18，在肠道疾病领域具有较大影响力。
辽宁省教学成果三等奖，第一指导教师荣获 “全国大学生基础医学创新研究暨实验设计论坛”总决赛“基础临床赛道”国家级铜奖；连续两年荣获 “挑战杯”全国大学生课外学术科技作品竞赛国家级三等奖。
下附代表性论文10篇1-11：
1 Cao W, Xiong Y，Chen D. Contradiction: Inhibiting inflammation and immunosuppression in the treatment of IBD. Proc Natl Acad Sci U S A 2024, 121(39): e2415439121.
2 Tong X, Zheng Y, Li Y, Xiong Y，Chen D. Soluble ligands as drug targets for treatment of inflammatory bowel disease. Pharmacol Ther 2021, 226: 107859.
3 Dong JY, Xia KJ, Liang W, Liu LL, Yang F, Fang XS, Xiong YJ, Wang L, Zhou ZJ, Li CY, Zhang WD, Wang JY，Chen DP. Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway. Acta Pharmacol Sin 2021, 42(9): 1461-1471.
4 Sui J, Zhang C, Fang X, Wang J, Li Y, Wang L, Dong J, Zhou Z, Li C, Chen J, Ma T，Chen D. Dual role of Ca(2+)-activated Cl(-) channel transmembrane member 16A in lipopolysaccharide-induced intestinal epithelial barrier dysfunction in vitro. Cell Death Dis 2020, 11(5): 404.
5 Xiong YJ, Deng ZB, Liu JN, Qiu JJ, Guo L, Feng PP, Sui JR, Chen DP，Guo HS. Enhancement of epithelial cell autophagy induced by sinensetin alleviates epithelial barrier dysfunction in colitis. Pharmacol Res 2019, 148: 104461.
6 Lu Y, Xiong Y, Zhang S, Wang B, Feng Y, Pu Z, Wei K, Chen J, Chen D，Zhang P. D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis. Front Pharmacol 2024, 15: 1454713.
7 Lu Y, Yang Y, Zhu G, Zeng H, Fan Y, Guo F, Xu D, Wang B, Chen D，Ge G. Emerging Pharmacotherapeutic Strategies to Overcome Undruggable Proteins in Cancer. Int J Biol Sci 2023, 19(11): 3360-3382.
8 Xiong Y, Qiu J, Li C, Qiu Y, Guo L, Liu Y, Wan J, Li Y, Wu G, Wang L, Zhou Z, Dong J, Du C, Chen D，Guo H. Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis. Front Immunol 2018, 9: 83.
9 Liu J, Sun L, Chen D, Huo X, Tian X, Li J, Liu M, Yu Z, Zhang B, Yang Y, Qiu Y, Liu Y, Guo H, Zhou C, Ma X，Xiong Y. Prdx6-induced inhibition of ferroptosis in epithelial cells contributes to liquiritin-exerted alleviation of colitis. Food Funct 2022, 13(18): 9470-9480.
10 Chen Y, Zhang G, Yang Y, Zhang S, Jiang H, Tian K, Arenbaoligao，Chen D. The treatment of inflammatory bowel disease with monoclonal antibodies in Asia. Biomed Pharmacother 2023, 157: 114081.
招生要求：希望具备团队精神、为人和善。英语六级通过者优先、有药理学相关研究经验者优先。
招生专业：动物学
联系方式：电子邮箱：cdp.9527@163.com
